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Angela Mabb

Assistant Professor    
Education

Postdoctoral Fellow, University of North Carolina, 2011 - 2016
Postdoctoral Fellow, Duke University, 2007 - 2011
Ph.D., University of Wisconsin-Madison, Molecular and Cellular Pharmacology, 2007
B.S., Clarkson University, Chemistry, 2002
B.S., Clarkson University, Bio-Molecular Science, 2002

Biography

Angela “Angie” Mabb recently joined the faculty ranks at Georgia State University in 2016 and is currently Assistant Professor at the Neuroscience Institute and Center for Behavioral Neurosciences. Angie received her undergraduate degree from Clarkson University dual majoring in Chemistry and Bio-Molecular Science. She then received her Ph.D. at the University of Wisconsin-Madison under the direction of Dr. Shigeki Miyamoto, where she focused on how posttranslational modifications contributed to pathways of chemoresistance in response to topoisomerase inhibitors.

Angie’s switch to the field of neuroscience dovetailed well with her graduate work, as she utilized her biochemical acumen to explore pathways of synaptic transmission and receptor trafficking in the nervous system at Duke University under the direction of Dr. Michael D. Ehlers. Here, she investigated how a group of enzymes called E3 ubiquitin ligases mediate synaptic transmission and plasticity in the nervous system. Her findings allowed a solution to a long-standing problem in the field of neuroscience: How can one temporally tune synaptic plasticity/transmission during elevated bouts of synaptic drive? While at Duke, Angie was a recipient of the Ruth K. Broad Fellowship and was awarded the National Service Research Award (NRSA) from the NIH/NINDS.

Angie then migrated to the University of North Carolina-Chapel Hill under the direction of Dr. Benjamin D. Philpot and Dr. Mark J. Zylka. Here she focused on understanding pathways involved in brain-specific epigenetic regulation, with a particular focus on the epigenetically imprinted E3, UBE3A, a gene whose dysfunction has been linked to autism, Angelman syndrome, and cervical cancer. While at UNC, she was the recipient of the Joseph E. Wagstaff Postdoctoral Fellowship from the Angelman Syndrome Foundation.

At GSU, Angie’s lab is focused on understanding how disruptions in ubiquitin pathways in the nervous system lead to a multitude of neurological disorders. Her approach is to utilize and develop molecular biology methods and tools to explore ubiquitin pathways involved in nervous system function and disease. In her lab, there is a strong emphasis on in vitro neuron culture preparations, generation of transgenic mouse models, imaging, and animal behavior.

Publications

Niedringhaus M, Dumitru R, Mabb AM, Wang Y, Philpot BD, Allbritton NL, Taylor AM. Transferable neuronal mini-cultures to accelerate screening in primary and induced pluripotent stem cell-derived neurons. Scientific Reports. 2015 Feb 10;5:8353.

Mabb AM, Kullmann PH, Twomey MA, Miriyala J, Philpot BD, Zylka MJ. Topoisomerase 1 inhibition reversibly impairs synaptic function. Proceedings of the National Academy of Sciences. 2014 Dec 2;111(48):17290-5.

Mabb AM*, Je HS*, Wall MJ, Robinson CG, Larsen RS, Qiang Y, Corrêa SA, and Ehlers MD. Triad3A regulates synaptic strength by ubiquitination of Arc. Neuron. 2014 Jun 18;82(6):1299-316.

King IF, Yandava CN, Mabb AM, Hsiao JS, Huang HS, Pearson BL, Calabrese JM, Starmer J, Parker JS, Magnuson T, Chamberlain SJ, Philpot BD, Zylka MJ. Topoisomerases Facilitate Transcription of Long Genes Linked to Autism. Nature. 2013 Sep 5;501(7465):58-62.

Huang H-S*, Allen JA*, Mabb AM, King IF, Miriyala JL, Taylor-Blake B, Sciaky N, Dutton JW, Lee H-M, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD. Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature. 2011 Dec 21;481(7380):185-9.

Lee MH, Mabb AM, Gill GB, Yeh ET, and Miyamoto S. NF-B Induction of the SUMO Protease SENP2: A Negative Feedback Loop to Attenuate Cell Survival Response to Genotoxic Stress. Molecular Cell. 2011 Jul 22;43(2):180-91.

Mabb AM*, Judson MC*, Zylka MJ, Philpot BD. Angelman Syndrome: Insights into Genomic Imprinting and Neurodevelopmental Phenotypes. Trends in Neuroscience. 2011 Jun;34(6):293-303. Review. Featured cover article.

Mabb AM and Ehlers MD. Ubiquitination in postsynaptic function and plasticity. Annual Review of Cell and Developmental Biology. 2010 Nov 10;26:179-210.

Mabb AM, Wuerzberger-Davis SM, Miyamoto S. PIASy mediates NEMO sumoylation and NF-B activation in response to genotoxic stress. Nature Cell Biology. 2006 Sep:8(9):986-93.

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