Angela MabbAssociate Professor Neuroscience
Postdoctoral Fellow, University of North Carolina, 2011 - 2016
Postdoctoral Fellow, Duke University, 2007 - 2011
Ph.D., University of Wisconsin-Madison, Molecular and Cellular Pharmacology, 2007
B.S., Clarkson University, Chemistry, 2002
B.S., Clarkson University, Bio-Molecular Science, 2002
Molecular Neuroscience, Neurological Disorders
Dr. Angela “Angie” Mabb joined the faculty at Georgia State University in 2016 and is currently 2CI Assistant Professor at the Neuroscience Institute and Center for Behavioral Neurosciences. Angie received her undergraduate degree from Clarkson University dual majoring in Chemistry and Bio-Molecular Science. She then received her Ph.D. at the University of Wisconsin-Madison under the direction of Dr. Shigeki Miyamoto, where she focused on how posttranslational modifications contributed to pathways of chemoresistance in response to topoisomerase inhibitors.
Dr. Mabb’s switch to the field of neuroscience dovetailed well with her graduate work, as she utilized her biochemical acumen to explore pathways of synaptic transmission and receptor trafficking in the nervous system at Duke University under the direction of Dr. Michael D. Ehlers. Here, she investigated how a group of enzymes called E3 ubiquitin ligases mediate synaptic transmission and plasticity in the nervous system. Her findings allowed a solution to a long-standing problem in the field of neuroscience: How can one temporally tune synaptic plasticity/transmission during elevated bouts of synaptic drive? While at Duke, Dr. Mabb was a recipient of the Ruth K. Broad Fellowship and was awarded the National Service Research Award (NRSA) from the NIH/NINDS.
Dr. Mabb then migrated to the University of North Carolina-Chapel Hill under the direction of Dr. Benjamin D. Philpot and Dr. Mark J. Zylka. Here she focused on understanding pathways involved in brain-specific epigenetic regulation, with a particular focus on the epigenetically imprinted E3, UBE3A, a gene whose dysfunction has been linked to autism, Angelman syndrome, and cervical cancer. While at UNC, she was the recipient of the Joseph E. Wagstaff Postdoctoral Fellowship from the Angelman Syndrome Foundation.
At GSU, Dr. Mabb’s lab is focused on understanding how disruptions in ubiquitin pathways in the nervous system lead to a multitude of neurological disorders. Her approach is to utilize and develop molecular biology methods and tools to explore ubiquitin pathways involved in nervous system function and disease. In Dr. Mabb’s lab, students will gain experience or have exposure to the following: primary neuron culture preparations, standard biochemical techniques, proteomics, confocal microscopy, use of transgenic mouse models, in vivo imaging, electrophysiology, and animal behavior. Research in the Mabb lab is currently funded by the NIH and NSF.
Deng X, Yao X-Q, Berglund K, Dong B, Ouedraogo D, Ghane MA, Zhuo Y, McBean C, Wei ZZ, Gozem S, Yu SP, Wei L, Fang N, Mabb AM, Gadda G, Hamelberg D, Yang JJ. Tuning protein dynamics to sense rapid calcium dynamics. Angew Chem Int Ed Engl. 2021 Aug 26. PubMed PMID: 28890418.
Mabb AM. Historical perspective and progress on ubiquitination at glutamatergic synapses. Neuropharmacology. 2021 Jun 29;196:108690. PubMed Central PMCID: PMC8831078.
Reddish FN, Miller CL, Deng X., Dong B, Patel AA, Ghane MA, Mosca B, McBean C, Wu S, Solntsev KM, Zhuo Y, Gadda G, Fang N, Cox DN, Mabb AM, Treves S, Zorzato F, Yang JJ. Rapid subcellular Calcium responses and dynamics by Calcium sensor G-CatchER+. iScience. 2021 Feb 3;24(3):102129. PubMed Central PMCID: PMC7900224.
Yakout DW, Shree N, Mabb AM. Effect of pharmacological manipulations on Arc function. Curr Res Pharmacol Drug Discov. 2020 Dec 24;2:100013. PubMed Central PMCID: PMC8663979.
Fragola G, Mabb AM, Taylor-Blake B, Niehaus J, Chronister W, Mao H, Simon J, Yuan H, Li Z, McConnell MJ, Zylka MJ. Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration. Nat Commun, 2020 Apr 23;11(1):1962 (2020). PubMed Central PMCID: PMC7181881.
Ghane MA, Yakout DW, Mabb AM. A High-content Assay for Monitoring AMPA Receptor Trafficking. J Vis Exp. 2019 Jan 28;(143). doi: 10.3791/59048. PubMed PMID: 30741265.
Wall MJ, Collins DR, Chery SL, Allen ZD, Pastuzyn ED, George AJ, Nikolova VD, Moy SS, Philpot BD, Shepherd JD, Müller J, Ehlers MD, Mabb AM*, Corrêa SAL*. The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility. Neuron. 2018 Jun 27;98(6):1124-1132.e7. doi: 10.1016/j.neuron.2018.05.012. Epub 2018 May 31. PubMed PMID: 29861284; PubMed Central PMCID: PMC6030446.
Mabb AM, Ehlers MD. Arc ubiquitination in synaptic plasticity. Semin Cell Dev Biol. 2018 May;77:10-16. doi: 10.1016/j.semcdb.2017.09.009. Epub 2017 Sep 7. Review. PubMed PMID: 28890418.
George AJ, Hoffiz YC, Charles AJ, Zhu Y, Mabb AM. A Comprehensive Atlas of E3 Ubiquitin Ligase Mutations in Neurological Disorders. Front Genet. 2018 Feb 14;9:29. doi: 10.3389/fgene.2018.00029. eCollection 2018. Review. PubMed PMID: 29491882; PubMed Central PMCID: PMC5817383.
Mabb AM, Kullmann PH, Twomey MA, Miriyala J, Philpot BD, Zylka MJ. Topoisomerase 1 inhibition reversibly impairs synaptic function. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17290-5. doi: 10.1073/pnas.1413204111. Epub 2014 Nov 17. PubMed PMID: 25404338; PubMed Central PMCID: PMC4260568.
Mabb AM*, Je HS*, Wall MJ, Robinson CG, Larsen RS, Qiang Y, Corrêa SA, Ehlers MD. Triad3A regulates synaptic strength by ubiquitination of Arc. Neuron. 2014 Jun 18;82(6):1299-316. doi: 10.1016/j.neuron.2014.05.016. PubMed PMID: 24945773; PubMed Central PMCID: PMC4277707.
King IF, Yandava CN, Mabb AM, Hsiao JS, Huang HS, Pearson BL, Calabrese JM, Starmer J, Parker JS, Magnuson T, Chamberlain SJ, Philpot BD, Zylka MJ. Topoisomerases facilitate transcription of long genes linked to autism. Nature. 2013 Sep 5;501(7465):58-62. doi: 10.1038/nature12504. Epub 2013 Aug 28. PubMed PMID: 23995680; PubMed Central PMCID: PMC3767287.
Huang HS, Allen JA, Mabb AM, King IF, Miriyala J, Taylor-Blake B, Sciaky N, Dutton JW Jr, Lee HM, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD. Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature. 2011 Dec 21;481(7380):185-9. doi: 10.1038/nature10726. PubMed PMID: 22190039; PubMed Central PMCID: PMC3257422.
Lee MH, Mabb AM, Gill GB, Yeh ET, Miyamoto S. NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress. Mol Cell. 2011 Jul 22;43(2):180-91. doi: 10.1016/j.molcel.2011.06.017. PubMed PMID: 21777808; PubMed Central PMCID: PMC3172129.
Mabb AM, Ehlers MD. Ubiquitination in postsynaptic function and plasticity. Annu Rev Cell Dev Biol. 2010;26:179-210. doi: 10.1146/annurev-cellbio-100109-104129. Review. PubMed PMID: 20604708; PubMed Central PMCID: PMC3163670.
Mabb AM, Wuerzberger-Davis SM, Miyamoto S. PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress. Nat Cell Biol. 2006 Sep;8(9):986-93. Epub 2006 Aug 13. PubMed PMID: 16906147.