Eric Krause
Professor GRA Distinguished Investigator- Education
2005 Ph.D. in Neuroscience, Florida State University, Tallahassee, Florida
2002 M.S. in Biological Psychology, Florida State University, Tallahassee, Florida
1999 B.A. in Psychology, Hiram College, Hiram, Ohio
- Specializations
Autonomic Neuroscience, Neuroendocrinology, Stress Neurobiology, Cardiovascular Science, Integrative Systems Physiology, Metabolism, Behavioral Neuroscience
- Biography
Eric G. Krause received a B.A. in psychology from Hiram College. He went on to receive a M.S. in biological psychology and a PhD in neuroscience from Florida State University. Subsequently, he completed postdoctoral training in the department of psychiatry and behavioral neuroscience at the University of Cincinnati. While at the University of Cincinnati, Krause was the recipient of the National Institutes of Health’s K99/R00 Pathways to Independence Award, which helped him secure a tenure-track faculty position at the University of Florida. During his 12 years at the University of Florida, Krause rose to the rank of tenured professor and was the founding director of the Center for Integrative Cardiometabolic Diseases. In the spring of 2023, Krause was recruited to Georgia State University as a core member of the Center for Neuroinflammation and Cardiometabolic Disease. Concurrently, he was appointed as an endowed Distinguished Investigator by the Georgia Research Alliance. Work from the Krause laboratory identifies novel therapeutic targets for a variety of disease conditions, including hypertension, obesity and mental health disorders.
Research Interests
Our research investigates neural circuits that promote susceptibility or resiliency to psychological and physiological stress. Towards this end, our work sheds light on health-related problems by conducting preclinical studies implementing an integrative approach. A combination of genetic tailoring, viral neuronal tract-tracing and advanced microscopy is used to reveal the connectivity of neurons implicated in the pathogenesis or reversal of stress-related disease. Optogenetics, chemogenetics, fMRI, and in vivo calcium imaging are used to determine how the activity of specific types of neurons is coupled to changes in physiology and behavior. Laboratory models of diseases (diet-induced obesity, social stressors) are used to understand the impact that stress has on gene expression, neuronal activity, and connectivity. The information gleaned from our studies is used to identify novel therapeutic targets and interventions that ease the burden of disease and improve health.
- Publications
For more publications, visit my Google Scholar page.
- Scott K.A., Tan Y., Johnson D.N., Elsaafien K., Baumer-Harrison C., Eikenberry S.A., de Lartigue G., de Kloet A.D., Krause E.G. Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice. bioRxiv preprint, 2023.
- Mohammed M., Johnson D.N., Wang L.A., Harden S.W., Sheng W., Spector E.A., Elsaafien K., Bader M., Steckelings U.M., Scott K.A., Frazier C.J., Sumners C., Krause E.G., de Kloet A.D. Targeting angiotensin type 2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice. Cardiovascular Research, 118(3):883896, 2022.
- Elsaafien K., Harden S.W., Johnson D.N., Kimball A.K., Sheng W., Smith J.A., Scott K.A., Frazier C.J., de Kloet A.D., Krause E.G. A novel organ-specific approach to selectively target sensory afferents innervating the aortic arch. Frontiers in Physiology, 13:841078, 2022.
- Elsaafien K., Kirchner M.K., Mohammed M., Eikenberry S.A., West C., Scott K.A., de Kloet A.D., Stern J.E., Krause E.G. Identification of novel cross-talk between the neuroendocrine and autonomic stress axes controlling blood pressure. The Journal of Neuroscience, 41;(21):4641-4657, 2021.
70. - Frazier C.J., Harden S.W., Alleyne A.R., Mohammed M., Sheng W., Smith J.A., Elsaafien K., Spector E.A., Johnson D.N., Scott K.A., Krause E.G., de Kloet A.D. An Angiotensin-Responsive Connection from the Lamina Terminalis to the Paraventricular Nucleus of the Hypothalamus Evokes Vasopressin Secretion to Increase Blood Pressure in Mice. The Journal of Neuroscience 41(7):1429-1442, 2021.
- Brierley D.I., Holt M.K., Singh A., de Araujo A., McDougle M., Vergara M., Afaghani M.H., Lee S.J., Scott K.A., Maske C., Langhans W., Krause E.G., de Kloet A.D., Gribble F.M., Reimann F., Rinaman L., de Lartigue G., Trapp S. Central and peripheral GLP-1 systems independently suppress eating. Nature Metabolism, (2):258-273, 2021. Sumners C., Alleyne A., Rodriguez V., Pioquinto D.J., Ludin J.A., Kar S., Winder Z., Ortiz Y., Krause E.G., de Kloet A.D. Brain angiotensin type-1 and type2 receptors: cellular locations under normal and hypertensive conditions. Hypertension Research 43(4):281-295, 2020.
- Futch H.S., McFarland K.N., Moore B.D., Kuhn M.Z., Giasson B.I., Ladd T.B., Scott K.A., Shapiro M.R., Nosacka, R.L., Goodwin M.S., Ran Y., Cruz P.E., Ryu D.H., Croft C.L., Levites Y., Janus C., Chakrabarty P., Judge A.R., Brusko T.M., de Kloet A.D., Krause E.G., Golde T.E. An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes. Journal of Experimental Medicine 21