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Kim Huhman

Professor    Distinguished University Professor    ,
Education

B.S. Zoology; Psychology Duke University 1982
Ph.D. Biological Psychology University of Georgia 1988

Specializations

Behavioral Neuroscience
Neuroendocrinology

Biography

Kim Levy Huhman was born and raised in Atlanta just a few miles from Georgia State University. She graduated from The Westminster Schools in Atlanta and Duke University, where she double-majored in Zoology and Psychology. It was at Duke that Dr. Huhman realized that she was fascinated by the relationship of brain to behavior. She went on to the University of Georgia Biological Psychology program, where she received her Ph.D. in 1988 in the laboratory of Dr. Bradford N. Bunnell. After obtaining her degree, Dr. Huhman was a National Research Council Fellow at the Walter Reed Army Institute of Research in the Division of Behavioral Neuroendocrinology. She then came to Georgia State University in 1991 to do a second postdoctoral fellowship in behavioral neuroscience in the laboratory of Dr. Elliott Albers. She was funded during this time with a Ruth Kirschstein National Research Service Award. In 1995, Dr. Huhman received independent funding for her research from the National Institutes of Health, and she transitioned into a faculty position. She is currently a Professor in the Neuroscience Institute and also holds an appointment in the Department of Psychology. She is currently the Past-President for the Atlanta Chapter of the Society for Neuroscience, and she has served on a variety of study sections to review grants for the National Institutes of Health including serving as a regular member of the NNRS (Neuroendocrinology, Neuroimmunology and Rhythms) Study Section.

Social stress is arguably the predominant form of stress encountered by mammals, and in humans this type of stress contributes to a variety of diseases and psychopathologies (e.g., heart disease, depression, anxiety disorders). Many animal models of human stress-related disorders use stressors such as intermittent foot shock, which offer the benefit of being highly controllable, but these laboratory stressors may bear little resemblance to the challenges that are naturally encountered by humans or non-humans. Animal models that use a social context closer to that which individuals might experience in their natural environment are essential to a better understanding of the neural mechanisms underlying social behavior, in general, and experience-dependent behavioral plasticity (or change), in particular. The Huhman lab studies in Syrian hamsters a phenomenon called conditioned defeat, which is an ethologically relevant model of stress-induced behavioral plasticity wherein a single, brief exposure to a social stressor reliably induces profound and long-lasting changes in social behavior. An overarching goal in our lab is to identify the neural circuit mediating conditioned defeat. We have demonstrated, for example, that the amygdala is critical to the acquisition and expression of conditioned defeat in hamsters, but there is also evidence that other brain areas are involved in the production of this behavioral change. We are also working 1) to determine in what part(s) of this neural circuit the critical plasticity occurs to mediate conditioned defeat and 2) to describe the cellular and molecular changes that underlie social stress-induced changes in behavior. We maintain that studying models such as conditioned defeat will improve our understanding of stress-related psychopathologies in humans and will ultimately lead to the development of better treatment options for these disorders.

Grant Funding

National Institute for Mental Health (NIMH) and Georgia State University Brains and Behavior Program Seed Grant

Publications

Representative Publications

McCann, K. E.; Rosenhauer, A. M.; Jones, G. M. F.; Norvelle, A.; Choi, D. C.; Huhman, K. L. Histone deacetylase and acetyltransferase inhibitors modulate behavioral responses to social stress. Psychoneuroendocrinology, 75:100-109, 2017.

Ross, A. P.; Norvelle, A.; Choi, D. C.; Walton, J. C.; Albers, H. E.; Huhman, K. L. Social housing and social isolation: Impact on stress indices and energy balance in male and female Syrian hamsters (Mesocricetus auratus). Physiology & Behavior, 177:264-269, 2017.

McCann, K. E.; Sinkiewicz, D. M.; Norvelle, A.; Huhman, K. L. De novo assembly, annotation, and characterization of the whole brain transcriptome of male and female Syrian hamsters. Scientific Reports, 7, 40472; doi: 10.1038/srep40472 (2017).

Rosenhauer, A.; McCann, K. E.; Norvelle, A.; Huhman, K. L. An acute social defeat stressor in early puberty increases susceptibility to social defeat in adulthood. Hormones and Behavior, 93, 31-38, 2017.

Partrick, K. A.; Chassaing, B.; Beach, L. Q.; McCann, K. E.; Gewirtz, A. T.; Huhman, K. L. Acute and repeated exposure to social stress reduces gut microbiota diversity in Syrian hamsters. Behavioural Brain Research, 345, 39-48, 2018.

McCann, K. E.; Sinkiewicz, D. M.; Rosenhauer, A. M.; Beach, L. Q.; Huhman, K. L. Transcriptomic analysis reveals sex-dependent expression patterns in the basolateral amygdala of dominant and subordinate animals after acute social conflict. Molecular Neurobiology, Epub ahead of print, DOI: 10.1007/s12035-018-1339-7

Rosenhauer, A. M.; Beach, L. Q.; Jeffress, E. C.; Thompson, B. M.; McCann, K. E.; Partrick, K. A.; Diaz, B.; Norvelle, A.; Choi, D. C.; Huhman, K. L. Brain-derived neurotrophic factor signaling mitigates the impact of social stress. Neuropharmacology, 148, 40-49, 2019.

Find Kim Huhman’s Publications on PubMed