1982 M.S. Chemical Engineering Technikum Winterthur, Switzerland
1989 Ph.D. Nucleic Acids Biochemistry University of Calgary, Canada
1990 Post Doc. Physical Biochemistry University of Calgary, Canada
DNA Damage, Unusual DNS Constituents, HIV-RNA Binding Zinc Fingers, RNA Structure
DNA damage: Effect on DNA structure and repair/recognition by repair enzymes.
Unusual DNA constituents: Study and control DNA stability, recognition and dynamics.
HIV- RNA binding Zinc fingers: Design, structure and combinatorial methods to generate small RREIIB RNA binding zinc fingers that inhibit rev binding and virus production.
RNA structure: RNA quadruples as therapeutic targets. West Nile Virus-host protein interaction.
Recent publications (out of 105):
•Harika, N. K, Boykin, D.W., Germann, M.W.* & Wilson, D.*: Structure of a Designed Minor Groove DNA GC base pair Specific Aza-Benzimidazole Derivative in Complex with the Target Sequence –AAGATA– (2017) Chemistry (2017), 23, 17612-20.
•Evich, M.G., Spring-Connell, A.M. & Germann, M.W.: Impact of modified ribose sugars on nucleic acid conformation and function. Heterocycles (2017), 23, 155-166. https://doi.org/10.1515/hc-2017-0056.
•Spring-Connell, A.M., Evich, M.G., Debelak, H., Seela, F. & Germann, M.W.: Using NMR and Molecular Dynamics to Link Structure and Dynamics Effects of the Universal Base 8-aza, 7-deaza, N8 linked Adenosine Analog. Nucleic Acids Research (2016), 44, 8576-8578.
•Evich, M, Spring-Connell, A.M., Francesca Storici, F., & Germann, M.W.: Structural impact of single ribonucleotides in DNA. ChemBioChem (2016), 17, 1968-1977.
•Thompson, R.A., Spring, A.M. Sheng, J., Huang, Z. & Germann, M.W.: “The Importance of Fitting In: Conformational Preference of Selenium 2’ Modifications in Nucleosides and Helical Structures” J. Biomolecular Structure and Dynamics (2015), 33, 289-297.
•Portella, G., Germann, M.W., Hud, N. V. & Orozco, M.: “MD and NMR Analysis of Choline and TMA Binding to Duplex DNA: On the Origins of Aberrant Sequence-Dependent Stability by Alkyl Cations in Aqueous and Water-Free Solvents”. JACS (2014), 136, 3075-3086.
•Rettig, M., Germann, M.W., Wang, S. & Wilson, W. D Molecular basis for sequence-dependent induced DNA bending. ChemBioChem (2013), 14, 323-331.
•Davis, W.G., Elizabeth J.E., E., Perelygin, A., Germann, M. W. & Brinton, M. A.: “A loop and two adjacent base pairs in the West Nile virus 3' terminal RNA structures facilitate eEF1A binding and viral minus strand RNA synthesis.” J. Virology, (2013), 87, 7622-36.
•Johnson, C.N., Spring, A.M., Desai, S., Cunningham, R.P. & Germann, M.W.: “DNA sequence context conceals anomeric lesions.” J. Mol. Biol. (2012) 416, 425-437.